Ultra Performance Convergence Chromatography (UPC2) is a new category of separations science in chromatography that makes the complex analysis routine. It combines the potential of SFC technique with available UPLC technique. Use of compressed carbon dioxide CO2 (green solvent) and co-solvent as a mobile phase makes the technique inexpensive and non toxic and it avoids use of toxic, expensive and volatile organic solvents. Along with sub-2 μm particle column chemistries, system gives the ability to precisely vary mobile phase strength, pressure, and temperature. With the ability to fine-tune the resolving power and selectivity of the system, one can exercise better control over the retention of analytes like natural products, traditional medicines, drugs, food additives or contaminants, pesticides, surfactants, polymer additives, or biofuels-all compounds that are often difficult to separate by any other means. It is also best complement to MS with low solvent load, high resolution, narrow peaks and fast separation. Waters Corporation has been awarded the prestigious 2012 Pittcon Editors’ Gold Award for the Waters ACQUITY UPC2 System as the best new product at the 2012 Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy.
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